The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps bring about a rise in methadone plasma concentrations, which could cause potentially lethal respiratory melancholy. On top of that, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may result i